CJC-1295
Research Overview
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids. It was originally developed by ConjuChem Biotechnologies and exists in two primary forms: CJC-1295 with DAC (Drug Affinity Complex) and CJC-1295 without DAC (also called Modified GRF 1-29). The DAC modification binds to albumin in the bloodstream, extending the peptide's half-life from approximately 30 minutes to 6-8 days.
The peptide works by stimulating the anterior pituitary gland to release growth hormone (GH) in a pulsatile pattern that mimics the body's natural rhythm. Unlike direct GH administration, CJC-1295 preserves the hypothalamic-pituitary feedback loop, meaning GH release is still regulated by somatostatin. This pulsatile release pattern is considered more physiological than exogenous GH, which produces a single sustained spike.
CJC-1295 is frequently used in research alongside growth hormone-releasing peptides (GHRPs) such as Ipamorelin or GHRP-6. The combination of a GHRH analog (CJC-1295) with a GHRP creates a synergistic effect, producing significantly greater GH release than either peptide alone.
Key Research Findings
- •Phase II clinical trial demonstrated sustained GH elevation for 6+ days after a single injection of CJC-1295 DAC (Teichman et al., 2006)
- •Increased IGF-1 levels by 40-100% above baseline in human subjects within one week of administration
- •CJC-1295 without DAC combined with Ipamorelin showed synergistic GH release 3-5x greater than either peptide alone in clinical studies
- •Preserved natural pulsatile GH release pattern unlike exogenous GH administration
- •Demonstrated dose-dependent increases in GH, IGF-1, and IGFBP-3 in healthy adults aged 21-61
- •No significant adverse effects on glucose metabolism or cortisol levels at therapeutic research doses
Research Dosage Protocols
CJC-1295 is available in two forms with distinct dosing protocols in research settings:
CJC-1295 with DAC: Due to its extended half-life (6-8 days), research protocols typically use doses of 1-2 mg administered once or twice weekly via subcutaneous injection. The prolonged albumin binding means it produces a sustained, continuous elevation of GH rather than acute pulses.
CJC-1295 without DAC (Mod GRF 1-29): With a much shorter half-life (~30 minutes), this form is typically dosed at 100-300 mcg per administration, often 1-3 times daily. It is frequently combined with Ipamorelin at similar doses to produce synergistic GH pulses.
Both forms are supplied as lyophilized powder and reconstituted with bacteriostatic water. Reconstituted solutions should be refrigerated at 2-8°C.
For research reference only. Not medical advice. Not for human consumption.
Published Research (1 studies)
- [1]Prolonged stimulation of GH, prolactin and cortisol by a single subcutaneous injection of CJC-1295— Teichman et al., 2006PMID: 16352683
Links go to PubMed (NIH National Library of Medicine). PeptideVerdict is not affiliated with these studies.
Price Comparison (70 products from 16 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Peptide Crafters | $45.00 $3.75/mg 12mg blend | In Stock |
| Triumphant Labs | $52.00 $5.20/mg 10mg | In Stock |
| Polaris Peptides | $60.00 $6.00/mg 10mg lyophilized | In Stock |
| Peptide Crafters | $30.00 $6.00/mg 5mg lyophilized | In Stock |
| Core Peptides | $73.00 $6.08/mg 12mg vial | In Stock |
| Core Peptides | $73.00 $6.08/mg 12mg vial | In Stock |
| Triumphant Labs | $61.00 $6.10/mg 10mg | In Stock |
| Core Peptides | $69.00 $6.90/mg 10mg vial | In Stock |
| Skye Peptides | $69.00 $6.90/mg 10mg lyophilized | In Stock |
| Simple Peptide | $35.00 $7.00/mg 5mg lyophilized | In Stock |
| Skye Peptides | $89.00 $7.12/mg 12.5mg lyophilized | In Stock |
| Paradigm Peptides | $35.99 $7.20/mg 5mg lyophilized | In Stock |
| Biotech Peptides | $87.00 $7.25/mg 12mg vial | In Stock |
| Biotech Peptides | $87.00 $7.25/mg 12mg vial | In Stock |
| Core Peptides | $73.00 $7.30/mg 10mg vial | In Stock |
| Core Peptides | $75.00 $7.50/mg 10mg vial | In Stock |
| Core Peptides | $80.00 $8.00/mg 10mg vial | In Stock |
| Biotech Peptides | $81.00 $8.10/mg 10mg vial | In Stock |
| Biotech Peptides | $81.00 $8.10/mg 10mg vial | In Stock |
| Core Peptides | $41.00 $8.20/mg 5mg vial | In Stock |
| Triumphant Labs | $41.00 $8.20/mg 5mg | In Stock |
| Core Peptides | $84.00 $8.40/mg 10mg vial | In Stock |
| Core Peptides | $84.00 $8.40/mg 10mg vial | In Stock |
| Biotech Peptides | $84.00 $8.40/mg 10mg vial | In Stock |
| Biotech Peptides | $84.00 $8.40/mg 10mg vial | In Stock |
| Biotech Peptides | $86.00 $8.60/mg 10mg vial | In Stock |
| Biotech Peptides | $86.00 $8.60/mg 10mg vial | In Stock |
| Core Peptides | $87.00 $8.70/mg 10mg vial | In Stock |
| Biotech Peptides | $80.00 $8.89/mg 9mg vial | In Stock |
| Core Peptides | $81.00 $9.00/mg 9mg vial | In Stock |
| Biotech Peptides | $109.00 $9.08/mg 12mg vial | In Stock |
| Biotech Peptides | $46.00 $9.20/mg 5mg vial | In Stock |
| Peptide Sciences | $95.00 $9.50/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $95.00 $9.50/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $95.00 $9.50/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $95.00 $9.50/mg 10mg lyophilized | In Stock |
| Core Peptides | $117.00 $9.75/mg 12mg vial | In Stock |
| Pure Rawz | $97.81 $9.78/mg 10mg vial | In Stock |
| Peptide Sciences | $49.50 $9.90/mg 5mg lyophilized | In Stock |
| BioLongevity Labs | $99.97 $10.00/mg 10mg vial | In Stock |
| Particle Peptides | $49.99 $10.00/mg 5mg lyophilized | In Stock |
| Core Peptides | $52.00 $10.40/mg 5mg vial | In Stock |
| Biotech Peptides | $52.00 $10.40/mg 5mg vial | In Stock |
| Peptide Sciences | $125.00 $10.42/mg 12mg lyophilized | In Stock |
| Peptide Partners | $220.00 $11.00/mg 20mg | In Stock |
| Peptide Crafters | $55.00 $11.00/mg 5mg lyophilized | In Stock |
| Peptide Partners | $117.00 $11.70/mg 10mg | In Stock |
| Astro Peptides | $25.00 $12.50/mg 2mg lyophilized | Out |
| Pure Rawz | $39.60 $13.20/mg 3mg vial | In Stock |
| Particle Peptides | $66.99 $13.40/mg 5mg lyophilized | In Stock |
| Pure Rawz | $108.44 $13.55/mg 8mg vial | In Stock |
| Simple Peptide | $70.00 $14.00/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $35.00 $17.50/mg 2mg lyophilized | In Stock |
| Swiss Chems | $42.95 $21.48/mg 2mg vial | In Stock |
| Swiss Chems | $47.95 $23.98/mg 2mg vial | In Stock |
| Triumphant Labs | $442.00 $44.20/mg 10mg | In Stock |
| Triumphant Labs | $519.00 $51.90/mg 10mg | In Stock |
| Triumphant Labs | $349.00 $69.80/mg 5mg | In Stock |
| Astro Peptides | $200.00 $100.00/mg 2mg lyophilized | Out |
| Peptide Sciences | $726.75 $145.35/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $726.75 $145.35/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $803.25 $160.65/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $811.75 $162.35/mg 5mg lyophilized | In Stock |
| Astro Peptides | $350.00 $175.00/mg 2mg lyophilized | Out |
| Pure Rawz | $281.19 $255.63/mg 1.1mg spray | In Stock |
| Peptide Sciences | $552.50 $276.25/mg 2mg lyophilized | In Stock |
| Peptide Sciences | $552.50 $276.25/mg 2mg lyophilized | In Stock |
| BioLongevity Labs | $199.97 $1333.13/mg 0.15mg vial | In Stock |
| Soma Chems | $54.99 vial | In Stock |
| Soma Chems | $29.99 vial | In Stock |
Frequently Asked Questions
What is the difference between CJC-1295 with DAC and without DAC?
CJC-1295 with DAC has a Drug Affinity Complex that binds to albumin, extending its half-life to 6-8 days and producing sustained GH elevation. CJC-1295 without DAC (Mod GRF 1-29) has a ~30-minute half-life and produces acute GH pulses. The 'without DAC' form is more commonly paired with GHRPs like Ipamorelin.
Why is CJC-1295 combined with Ipamorelin?
CJC-1295 (a GHRH analog) and Ipamorelin (a GHRP) work through different receptor pathways. When combined, they produce synergistic GH release 3-5x greater than either peptide alone, mimicking the body's natural dual-signal system for GH secretion.
Where can I buy CJC-1295 for research?
CJC-1295 is one of the most widely available research peptides. Compare prices across verified vendors in the table above — note whether listings specify 'with DAC' or 'without DAC' as they are different products.
Has CJC-1295 been tested in humans?
Yes. CJC-1295 DAC completed Phase II clinical trials showing sustained GH and IGF-1 elevation in healthy adults. However, further clinical development was discontinued. The data from these trials is published and publicly available.