Epitalon — Vendor Pricing & Purity Guide
Research Overview
Epitalon (also spelled Epithalon or Epithalone) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Dr. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in Russia. It is a synthetic version of the naturally occurring peptide Epithalamin, which is extracted from the pineal gland. Epitalon is the most extensively studied peptide in the field of bioregulatory peptide therapy and anti-aging research.
The peptide's primary mechanism involves activation of telomerase, the enzyme responsible for maintaining telomere length. Telomeres are the protective caps at the ends of chromosomes that shorten with each cell division — a process directly linked to cellular aging. By activating telomerase, Epitalon has been shown to elongate telomeres in human somatic cells, effectively resetting one of the fundamental clocks of cellular aging.
Beyond telomerase activation, Epitalon regulates melatonin production in the pineal gland, normalizes circadian rhythm function, and influences the neuroendocrine system. Khavinson's research group has published over 100 papers on Epitalon and related bioregulatory peptides, including long-term studies spanning decades in both animal models and human populations.
Key Research Findings
- •Activated telomerase and elongated telomeres in human fetal lung fibroblast cells, extending their replicative lifespan by 44% (Khavinson et al., 2003)
- •Increased lifespan by 13.3% in aged mice when administered late in life (Anisimov et al., 2001)
- •Restored melatonin production to youthful levels in aged primates and human subjects
- •Reduced tumor incidence in rodents predisposed to spontaneous cancers across multiple long-term studies
- •Normalized cortisol rhythms and improved sleep quality in elderly human subjects
- •20-year longitudinal study of bioregulatory peptides (including Epithalamin) showed 28% reduction in mortality in elderly patients
Research Dosage Protocols
Epitalon is supplied as lyophilized powder and reconstituted with bacteriostatic water for subcutaneous or intramuscular injection.
In published research, the most common protocol involves 5-10 mg administered daily for 10-20 day courses, repeated 2-3 times per year. This cyclical approach is consistent with Russian bioregulatory peptide therapy protocols, which emphasize periodic short courses rather than continuous administration.
Epitalon is also available in oral and nasal forms, though subcutaneous injection is the most studied route. The peptide is considered to have a favorable safety profile in published research, with no significant adverse effects reported across decades of study.
For research reference only. Not medical advice. Not for human consumption.
Published Research (2 studies)
- [1]Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells— Khavinson et al., 2003PMID: 14523363
- [2]Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice— Anisimov et al., 2003PMID: 12614630
Links go to PubMed (NIH National Library of Medicine). PeptideVerdict is not affiliated with these studies.
Price Comparison (20 products from 14 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Peptide Crafters | $115.00 $1.44/mg 80mg lyophilized | In Stock |
| Pure Rawz | $216.26 $1.44/mg 150mg vial | In Stock |
| Swiss Chems | $23.16 $2.32/mg 10mg vial | In Stock |
| Paradigm Peptides | $24.00 $2.40/mg 10mg lyophilized | In Stock |
| Polaris Peptides | $125.00 $2.50/mg 50mg lyophilized | In Stock |
| Pure Rawz | $57.39 $2.87/mg 20mg vial | In Stock |
| Simple Peptide | $33.00 $3.30/mg 10mg lyophilized | In Stock |
| Polaris Peptides | $35.00 $3.50/mg 10mg lyophilized | In Stock |
| Core Peptides | $90.00 $3.60/mg 25mg vial | In Stock |
| Biotech Peptides | $94.00 $3.76/mg 25mg vial | In Stock |
| Particle Peptides | $41.99 $4.20/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $215.00 $4.30/mg 50mg lyophilized | In Stock |
| BioLongevity Labs | $94.97 $4.75/mg 20mg vial | In Stock |
| Peptide Sciences | $95.00 $4.75/mg 20mg lyophilized | In Stock |
| Peptide Sciences | $100.00 $5.00/mg 20mg lyophilized | In Stock |
| Pure Rawz | $311.31 $9.79/mg 31.8mg vial | In Stock |
| Peptide Sciences | $140.00 $140.00/mg 1mg capsule | In Stock |
| Soma Chems | $49.99 vial | In Stock |
| Apollo Peptide Sciences | $139.99 vial | In Stock |
| Skye Peptides | $69.00 lyophilized | In Stock |
Frequently Asked Questions
What is Epitalon?
Epitalon is a synthetic tetrapeptide that activates telomerase, the enzyme that maintains telomere length. It was developed in Russia from pineal gland extracts and has been studied for anti-aging, melatonin regulation, and lifespan extension.
Does Epitalon really lengthen telomeres?
In vitro studies have demonstrated telomerase activation and telomere elongation in human cells. Whether this translates to meaningful clinical anti-aging effects in humans remains under investigation, though long-term observational studies of the related peptide Epithalamin showed reduced mortality.
How often should Epitalon be administered in research?
Published protocols typically use 10-20 day courses repeated 2-3 times per year. This cyclical approach is standard for Russian bioregulatory peptides, which are designed for periodic rather than continuous use.
Where can I buy Epitalon for research?
Epitalon is available from research peptide vendors. Compare pricing in the table above.