TRH — Vendor Pricing & Purity Guide
Research Overview
TRH (Thyrotropin-Releasing Hormone, also called Protirelin) is a tripeptide (pGlu-His-Pro) produced by the hypothalamus. Its primary endocrine function is stimulating the anterior pituitary to release TSH (thyroid-stimulating hormone) and prolactin. However, TRH also functions as a neuromodulator with effects on arousal, mood, thermoregulation, and nociception independent of thyroid function.
TRH has been studied for depression, spinal cord injury, and neurodegenerative conditions. Its rapid antidepressant effect in clinical studies preceded the discovery of ketamine's similar rapid-acting mechanism by decades.
Key Research Findings
- •FDA-approved diagnostic agent for thyroid function (Protirelin)
- •Demonstrated rapid antidepressant effects in clinical studies — preceding ketamine research by decades
- •Neuroprotective in spinal cord injury and traumatic brain injury animal models
- •Neuromodulatory effects independent of thyroid axis — affects arousal, mood, and pain
Research Dosage Protocols
TRH is FDA-approved as a diagnostic agent (Protirelin, 200-500 mcg IV bolus). Research protocols for neuromodulatory effects use similar or lower doses via IV or intranasal routes.
For research reference only. Not medical advice. Not for human consumption.
Price Comparison (4 products from 3 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Core Peptides | $73.00 $2.92/mg 25mg vial | In Stock |
| Biotech Peptides | $93.00 $3.72/mg 25mg vial | In Stock |
| Peptide Sciences | $200.00 $4.00/mg 50mg lyophilized | In Stock |
| Peptide Sciences | $95.00 $4.75/mg 20mg lyophilized | In Stock |
Frequently Asked Questions
What is TRH?
TRH is a hypothalamic tripeptide that stimulates TSH release. Beyond thyroid function, it has neuromodulatory effects on mood, arousal, and pain. It showed rapid antidepressant effects decades before ketamine.