KPV — Vendor Pricing & Purity Guide
Research Overview
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). It is one of the smallest bioactive peptides studied for anti-inflammatory activity, consisting of only three amino acids. Despite its minimal size, KPV has demonstrated potent anti-inflammatory effects in multiple disease models, particularly inflammatory bowel disease (IBD).
KPV's mechanism centers on inhibition of NF-κB, the master transcription factor for inflammatory gene expression. It enters cells through the peptide transporter PepT1, which is highly expressed in intestinal epithelial cells, making it particularly effective in the gut. Once inside the cell, KPV directly interferes with NF-κB nuclear translocation, suppressing the production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6.
The peptide's small size gives it advantages over larger anti-inflammatory peptides: it is more stable, less immunogenic, and has been shown to maintain activity when administered orally — a rarity for peptides. This oral bioavailability, combined with its gut-specific PepT1 uptake, makes KPV particularly interesting for inflammatory bowel disease research.
Key Research Findings
- •Reduced colonic inflammation comparable to standard IBD treatments in DSS-induced colitis mouse models (Dalmasso et al., 2008)
- •Entered intestinal epithelial cells via PepT1 transporter, concentrating anti-inflammatory activity in the gut
- •Inhibited NF-κB activation in multiple cell types, suppressing TNF-α, IL-1β, and IL-6 production
- •Demonstrated anti-inflammatory activity via oral administration in rodent models — unusual for peptides
- •Reduced inflammatory markers when loaded into nanoparticles for targeted colonic delivery
- •Showed wound-healing properties in intestinal epithelial cell models through enhanced cell migration
Research Dosage Protocols
KPV is supplied as lyophilized powder and can be reconstituted with bacteriostatic water for subcutaneous injection or prepared for oral administration.
Published research protocols for IBD models have used doses ranging from 50 mcg to 500 mcg per administration in rodent studies. The peptide has been studied via subcutaneous injection, oral administration, and nanoparticle-encapsulated colonic delivery.
KPV's small size (only 3 amino acids) gives it relatively good stability compared to larger peptides. It is frequently studied alongside BPC-157 for gut-related inflammation research, though they work through different mechanisms — KPV through NF-κB inhibition and BPC-157 through the NO/FAK-paxillin pathway.
For research reference only. Not medical advice. Not for human consumption.
Published Research (1 studies)
- [1]Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects— Brzoska et al., 2008PMID: 18489350
Links go to PubMed (NIH National Library of Medicine). PeptideVerdict is not affiliated with these studies.
Price Comparison (17 products from 15 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Paradigm Peptides | $39.99 $4.00/mg 10mg lyophilized | In Stock |
| Peptide Crafters | $40.00 $4.00/mg 10mg lyophilized | In Stock |
| Triumphant Labs | $41.00 $4.10/mg 10mg | In Stock |
| Simple Peptide | $45.00 $4.50/mg 10mg lyophilized | In Stock |
| Polaris Peptides | $55.00 $5.50/mg 10mg lyophilized | In Stock |
| Particle Peptides | $31.99 $6.40/mg 5mg lyophilized | In Stock |
| Peptide Partners | $88.00 $8.80/mg 10mg | In Stock |
| Core Peptides | $38.00 $9.50/mg 4mg vial | In Stock |
| Biotech Peptides | $39.00 $9.75/mg 4mg vial | In Stock |
| BioLongevity Labs | $99.97 $10.00/mg 10mg vial | In Stock |
| Peptide Sciences | $55.00 $11.00/mg 5mg lyophilized | In Stock |
| Triumphant Labs | $345.00 $34.50/mg 10mg | In Stock |
| Swiss Chems | $139.95 $559.80/mg 0.25mg capsule | In Stock |
| Limitless Biotech | $143.00 $572.00/mg 0.25mg capsule | Out |
| Soma Chems | $199.99 vial | In Stock |
| Soma Chems | $54.99 vial | In Stock |
| Skye Peptides | $54.00 lyophilized | In Stock |
Frequently Asked Questions
What is KPV?
KPV is a tripeptide (Lys-Pro-Val) derived from alpha-MSH with potent anti-inflammatory properties. It inhibits NF-κB signaling and is particularly studied for inflammatory bowel disease due to its gut-specific uptake through the PepT1 transporter.
Can KPV be taken orally?
Research in rodent models has shown KPV maintains anti-inflammatory activity via oral administration, which is unusual for peptides. Its small size (3 amino acids) and PepT1-mediated intestinal uptake contribute to its oral bioavailability.
How does KPV compare to BPC-157 for gut inflammation?
Both are studied for gut healing but work through different mechanisms. KPV inhibits NF-κB (the master inflammatory switch). BPC-157 promotes angiogenesis and tissue repair via the NO system. They target different aspects of the inflammatory/healing process.
Where can I buy KPV for research?
KPV is available from research peptide vendors. Compare pricing in the table above.