TB-500
Research Overview
TB-500 is a synthetic version of Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide naturally present in nearly all human and animal cells. Thymosin Beta-4 is one of the most abundant intracellular peptides and plays a central role in cell migration, tissue repair, and inflammation modulation. TB-500 specifically replicates the active region (amino acids 17-23) of the full Thymosin Beta-4 protein.
The peptide's primary mechanism involves binding to and sequestering actin monomers, which promotes cell migration to sites of injury. It upregulates actin, a protein that forms the cytoskeleton and is essential for cell motility. This actin-regulating activity drives TB-500's observed effects on wound healing, angiogenesis (new blood vessel formation), and anti-inflammatory response. TB-500 also promotes differentiation of stem cells and reduces apoptosis in damaged tissues.
TB-500 has been extensively studied in equine medicine for tendon and ligament repair. It is also one of the most popular research peptides in the bodybuilding and biohacking communities, often used alongside BPC-157 as a "healing stack." The two peptides work through complementary mechanisms — TB-500 through actin regulation and cell migration, BPC-157 through the NO/FAK-paxillin pathway and angiogenesis.
Key Research Findings
- •Accelerated dermal wound healing by 42% in diabetic mouse models (Philp et al., 2004)
- •Reduced infarct size and improved cardiac function after myocardial infarction in rodent models
- •Promoted hair regrowth in mouse models through stimulation of hair follicle stem cells
- •Demonstrated significant anti-inflammatory activity by suppressing NF-κB and reducing pro-inflammatory cytokines
- •Improved corneal wound healing and reduced scarring in rabbit eye injury models
- •Enhanced tendon repair strength by 40-60% in equine studies, leading to widespread veterinary use
- •Showed neuroprotective effects and improved functional recovery after spinal cord injury in rats
Research Dosage Protocols
In published animal research, TB-500 has been administered at a wide range of doses depending on the model and target tissue. Common research protocols in rodent studies use 1-5 mg/kg body weight.
TB-500 is typically supplied as a lyophilized powder and reconstituted with bacteriostatic water. The peptide is generally administered via subcutaneous or intraperitoneal injection in animal studies. It has a relatively long biological half-life compared to many peptides, and research protocols often use a "loading" approach followed by less frequent maintenance doses.
TB-500 is frequently studied alongside BPC-157, as the two peptides appear to have complementary mechanisms of action for tissue repair. BPC-157 primarily drives angiogenesis and operates through the nitric oxide system, while TB-500 promotes cell migration through actin regulation.
For research reference only. Not medical advice. Not for human consumption.
Published Research (3 studies)
- [1]Thymosin beta4 increases hair growth by activation of hair follicle stem cells— Philp et al., 2004PMID: 15175256
- [2]Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair— Bock-Marquette et al., 2004PMID: 15496926
- [3]
Links go to PubMed (NIH National Library of Medicine). PeptideVerdict is not affiliated with these studies.
Price Comparison (30 products from 17 vendors)
| Vendor | Price | Stock |
|---|---|---|
| Pure Rawz | $45.33 $3.02/mg 15mg vial | In Stock |
| Astro Peptides | $50.00 $5.00/mg 10mg lyophilized | In Stock |
| Triumphant Labs | $58.00 $5.80/mg 10mg | In Stock |
| Peptide Crafters | $65.00 $6.50/mg 10mg lyophilized | In Stock |
| Paradigm Peptides | $65.00 $6.50/mg 10mg lyophilized | In Stock |
| Skye Peptides | $69.00 $6.90/mg 10mg lyophilized | In Stock |
| Polaris Peptides | $70.00 $7.00/mg 10mg lyophilized | In Stock |
| Swiss Chems | $38.95 $7.79/mg 5mg vial | In Stock |
| Particle Peptides | $79.99 $8.00/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $100.00 $10.00/mg 10mg lyophilized | In Stock |
| Biotech Peptides | $124.00 $12.40/mg 10mg vial | In Stock |
| Peptide Partners | $130.00 $13.00/mg 10mg | In Stock |
| Biotech Peptides | $72.00 $14.40/mg 5mg vial | In Stock |
| Core Peptides | $78.00 $15.60/mg 5mg vial | In Stock |
| BioLongevity Labs | $164.97 $16.50/mg 10mg vial | In Stock |
| Peptide Sciences | $165.00 $16.50/mg 10mg lyophilized | In Stock |
| Peptide Sciences | $85.00 $17.00/mg 5mg lyophilized | In Stock |
| Triumphant Labs | $493.00 $49.30/mg 10mg | In Stock |
| Astro Peptides | $720.00 $72.00/mg 10mg lyophilized | In Stock |
| Astro Peptides | $400.00 $80.00/mg 5mg lyophilized | In Stock |
| Astro Peptides | $1296.00 $129.60/mg 10mg lyophilized | In Stock |
| Astro Peptides | $720.00 $144.00/mg 5mg lyophilized | In Stock |
| Peptide Sciences | $160.00 $320.00/mg 0.5mg capsule | In Stock |
| Swiss Chems | $254.95 $509.90/mg 0.5mg capsule | In Stock |
| Soma Chems | $64.99 spray | In Stock |
| Soma Chems | $44.99 vial | In Stock |
| Swiss Chems | $23.96 vial | In Stock |
| Apollo Peptide Sciences | $59.99 vial | In Stock |
| Skye Peptides | $69.00 lyophilized | In Stock |
| Simple Peptide | $65.00 lyophilized | In Stock |
Frequently Asked Questions
What is TB-500?
TB-500 is a synthetic peptide based on the active region of Thymosin Beta-4, a naturally occurring protein involved in cell migration, tissue repair, and inflammation. It has been studied primarily in animal models for wound healing, cardiac repair, and tendon recovery.
What is the difference between TB-500 and Thymosin Beta-4?
TB-500 is a synthetic fragment representing the active 7-amino-acid region (17-23) of the full 43-amino-acid Thymosin Beta-4 protein. They share the same core mechanism of action, but TB-500 is shorter and more commercially practical to synthesize.
Can TB-500 and BPC-157 be used together in research?
Yes, they are frequently studied together as they work through complementary pathways. BPC-157 promotes healing via angiogenesis and the NO system, while TB-500 drives cell migration through actin regulation. Combination studies have shown enhanced tissue repair compared to either peptide alone.
Where can I buy TB-500 for research?
TB-500 is widely available from research peptide vendors. Compare current prices across vendors in the table above, sorted by price per milligram.